ST. LOUIS – The Dome at America’s Center is hosting a mass COVID-19 vaccination event next week, run by the Federal Emergency Management Agency, and city officials are urging people to register now for their doses. Advance registration is required.
The site will open Wednesday, April 7, and run from 8 a.m. to 6 p.m., seven days a week, inside the concourse level of the Dome at the corner of Broadway and Cole Street. Free parking will be available, with wheelchair access.
Appointments are being scheduled now for city residents. Which COVID-19 vaccine people get will depend on which is available.
People can register on Missouri’s Vaccine Navigator website: https://covidvaccine.mo.gov/navigator/, or call 877-435-8411. After registering, people will be contacted about their appointment date and time. Even if a person has already signed up for the vaccine with the city’s online pre-registration and notification system, FEMA is asking that they also register on the Vaccine Navigator.
“We think that that’s going to be able to reach almost everybody in the city of St. Louis who wants a vaccination,” Mayor Lyda Krewson said. “It really should give everybody the opportunity to get a vaccination right here, close to home.”

About 880,000 Missourians are newly eligible for vaccine under Phase 2 of Missouri’s plan. The group includes employees in sectors such as construction, critical manufacturing and financial services, as well as restaurant workers, higher education workers, library staff and government workers. It also includes homeless people, and others disproportionately vulnerable to infection.
On April 9, all Missourians 16 and older are expected to become eligible for vaccines, as the state opens Phase 3.